MIB-1 proliferative activity in invasive breast cancer measured by image analysis.

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MIB-1 proliferative activity in invasive breast cancer measured by image analysis.

AIMS To determine cell proliferation in infiltrating breast carcinomas. METHODS Using the MIB-1 monoclonal antibody, the proliferation index was measured in paraffin wax sections of 871 breast cancers. The MIB-1 proliferation index was compared with other markers of disease progression: size, lymph node status, histotype, oestrogen and progesterone receptor status, expression of p53 and Neu, ...

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Tissue microarray technique in evaluation of proliferative activity in invasive ductal breast cancer.

AIM Investigation of the relationship between expression of Ki-67 antigen and minichromosome maintenance 2 (MCM-2) protein by using an immunohistochemical study on whole sections (WS) and sections of invasive ductal breast cancer (IDC) obtained in the tissue microarray (TMA) technique. MATERIALS AND METHODS Material consisted of 51 archival paraffin blocks of IDC. Tissue microarrays were comp...

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Pediatric Meduloblastoma and the Prognostic Value of MIB-1 Proliferative Factor

Background: Medulloblastoma is the most common malignant brain tumor in children. The important factors in predicting survival are the extent of disease, proliferation index of the tumor cells, histopathologic class and the age at diagnosis. The percentage of Ki-67 positive cells reflects the proliferation  of the cells and is one of the critical factors which determine the growth of the tumor....

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Estrogen Receptor-Negative Breast Ductal Carcinoma: Clinicopathological Features and Mib-1 (Ki-67) Proliferative Index Association

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopath...

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Proliferative activity and apoptosis of Langerhans histiocytes in eosinophilic granulomas as evaluated by MIB-1 and TUNEL methods.

Aims-To identify the role played by apoptosis in tumour regression.Methods-The growth fraction and apoptotic cell loss of four cases of eosinophilic granuloma were investigated using monoclonal antibodies against Ki-67 proliferation marker (MIB-1) antigen and the TdT mediated dUTP-biotin 3'-OH nick end labelling (TUNEL) method. These data were then compared with the clinical growth rate.Results...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1996

ISSN: 0021-9746

DOI: 10.1136/jcp.49.11.926